Senior Researcher/Associate Director/Director of Tumor Immunity

Responsibilities

  1. Have a sufficient understanding of the principles of immunology, and lead the development and evaluation of new tumor immunotherapies, especially the tumor immune microenvironment, tumor-related macrophages and dendritic cells (CDC, PDC, MDSC, etc.);
  2. Responsible for immune tumor related experimental operations such as MLR, ELISA, Elispot, T cell sorting and culture, T cell killing, activation and costimulation. Experimental results and data analysis to prove the concept and explain the mechanism;
  3. It is possible to establish in vitro immune detection methods or animal models of tumor immune diseases;
  4. On the basis of existing models, establish novel in vivo or in vitro screening platforms, and use these platforms to identify and characterize the functions and therapeutic potential of new drugs in the fields of B cell, T cell and innate immune cell biology;
  5. Identify new targets, new drug molecules and signal pathways in the tumor immune response;
  6. Research and analyze the mechanism of action of new drugs, be responsible for writing related SOPs for experiments, and be able to submit new drug INDs;
  7. Demonstrate the team spirit of scientists by guiding, training or motivating team members, and be able to cultivate the experimental and analytical capabilities of team members.

Requirements

  1. A doctor with a background in immunology from a domestic university or a foreign university or a master’s degree with more than 5 years of work experience; excellent scientific research ability, and no less than 1 article on tumor immunity with an IF score of 5 or more;
  2. Solid immunology experimental skills, flow cytometry (more than 8 colors), independent analysis of immune cell subpopulations, proficient use of FlowJo (modulation compensation, t-SNE, etc.), purification, sorting and culture of primary cells, Immune cell culture, co-cultivation experiments have good consistency and repeatability, and establish in vivo disease models;
  3. Independently plan and execute the screening and evaluation of immunomodulatory compounds; identify new targets, new drug molecules and signal pathways in the tumor immune response;
  4. According to the company’s needs, investigate the research progress of new tumor immunology projects and targets at home and abroad, and write project approval and closing reports;
  5. Excellent communication and interpersonal skills, able to present research results in intra-departmental and inter-departmental meetings.